2010年9月3日 星期五

腸躁症(IBS)發生的真正原因在腸道而非心理因素

        2010年8月25日慕尼黑工業大學Tamira K Klooker等人,發表在英國醫學期刊--- Gut雜誌,指出腸躁症的真正原因,是由於腸道黏膜發炎,造成腸道敏感所致。是故許多醫師已經不再將腸躁症患者歸類為心理疾患。

        研究方法是將60名受試者分成兩組,一組給予Ketotifen(一種抗組織胺藥物,可抑制發炎及過敏現象),另一組給予安慰劑(不具藥效)共8周,結果發現,Ketotifen組可明顯減緩腸躁症的不適症狀,改善患者生活品質,但是服用安慰劑組患者卻沒有的改善。

       大腸激躁症的原因是因為腸道中的黏膜發炎,而黏膜中的肥大細胞(Mast Cell)會不斷分泌如血清素(Serotonin)、組織胺(Histamine)、substance P、calcitonin gene-related peptide (CGRP)、cholecystokinin (CCK)、神經激肽(neurokinins)等物質,進而破壞腸道中的敏感性平衡,使腸道蠕動不正常,還會因為包括胃脹氣、噁心、睡眠障礙、腹絞痛,甚至交替著腹瀉或便秘等不適症狀,而大大影響心情,破壞生活品質。

      所以,不要再說因為緊張或是壓力,而導致腸躁症的發生,根本的問題,還是出在腸道太敏感,平常應避免刺激性與辛辣性飲食、遠離菸、酒、咖啡因飲料;充足的睡眠和適度的運動,都可以有效控制腸躁症的發生喔~~~





資料來源:Tamira K Klooker et al., The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome.
Gut 2010;59:1213-1221 doi:10.1136/gut.2010.213108

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